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A Simple Device to Rapidly Prepare Whole Mounts of the Mouse Intestine
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Naturally occurring intestinal epithelial neoplasms in aged Crl:CD BR rats

G M Zwicker1, R C Eyster, D M Sells

  • 1Toxicology Department, Marion Merrell Dow, Inc., Indianapolis, Indiana 46268.

Toxicologic Pathology
|January 1, 1992
PubMed

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The intestinal epithelial lining rapidly renews every 4 to 5 days. The renewal is facilitated by intestinal stem cells (ISCs) located at the base of the crypt– a gland located at the bottom of each villus. ISCs divide asymmetrically to form new stem cells and progenitor daughter cells. The daughter cells are called transit-amplifying (TA) cells which move upwards along the crypt and either differentiate into absorptive cells– the enterocytes or secretory cells– including the goblet,...