Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

Mesenteric lymph node hemangiomas of Wistar rats.

J F Reindel¹, M A Dominick, A W Gough

¹Parke-Davis Pharmaceutical Research Division, Warner-Lambert Company, Ann Arbor, Michigan 48105.

Toxicologic Pathology

|January 1, 1992

Summary

Vascular tumors in Wistar rats are uncommon, primarily affecting mesenteric lymph nodes. These neoplasms occurred more frequently in males and showed varied histological features, with rare instances of aggressive characteristics or rupture.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Meeting report: Spontaneous lesions and diseases in wild, captive-bred, and zoo-housed nonhuman primates and in nonhuman primate species used in drug safety studies.

Veterinary pathology·2012

Same author

Rodent carcinogenicity with the thiazolidinedione antidiabetic agent troglitazone.

Toxicological sciences : an official journal of the Society of Toxicology·2002

Same author

Systemic proliferative changes and clinical signs in cynomolgus monkeys administered a recombinant derivative of human epidermal growth factor.

Toxicologic pathology·2001

Same author

Growth and development in rats given recombinant human epidermal growth factor(1-48) as neonates.

Toxicological sciences : an official journal of the Society of Toxicology·2001

Same author

RNA expression in the early characterization of hepatotoxicants in Wistar rats by high-density DNA microarrays.

Hepatology (Baltimore, Md.)·2001

Same author

Evaluation of toxicokinetic variables and arthropathic changes in juvenile rabbits after oral administration of an investigational fluoroquinolone, PD 117596.

American journal of veterinary research·2000

Area of Science:

Veterinary Pathology
Oncology
Rodent Models

Background:

Vascular tumors in rodent mesenteric lymph nodes are rare.
This study analyzes 57 such neoplasms identified in Wistar rats across multiple bioassays.

Purpose of the Study:

To characterize the incidence, morphology, and behavior of vascular tumors in Wistar rat mesenteric lymph nodes.
To identify any potential risk factors or aggressive features associated with these tumors.

Main Methods:

Retrospective analysis of neoplastic lesions from control and treated Wistar rats.
Histopathological examination of tumors, including assessment of invasion and mitotic activity.
Gross necropsy findings were also recorded.

Main Results:

Related Experiment Videos

Tumor incidence ranged from 0.75% to 5.50%, with a 2:1 male-to-female ratio.
Lesions were typically solitary, confined to nodal/perinodal tissue, and histologically characterized as cavernous hemangiomas or tumors with aggressive features.
Metastasis was not observed; fatal tumor rupture occurred in one rat.

Conclusions:

Vascular tumors of the mesenteric lymph node in Wistar rats are uncommon but present with diverse histological features.
While generally benign, some tumors exhibit potentially aggressive characteristics, necessitating careful histopathological evaluation.