Related Experiment Video
Updated: Aug 29, 2026

Growing a Cystic Fibrosis-Relevant Polymicrobial Biofilm to Probe Community Phenotypes
Published on: April 19, 2024
[Mucoviscidosis: Background, risk factors, diagnosis strategy, treatment principles]
1Disciplina de Pneumoftiziologie, Facutatea de Medicină Stomatologică, Universitatea de Medicină şi Farmacie Gr.T. Popa Iaşi.
Abstract:
Known as a systemic disease, genetically conditioned, mucoviscidosis or cystic fibrosis brings together chronic obstructive bronchopathy, manifested since early childhood, chronic bronchial infection especially with pseudomonas or staphylococcus aureus, pancreatic impairment and a high clorum ratio in sweats. Cystic fibrosis transmembrane conductance regulator is inducing the disease, 1 of 20 caucasians being carriers of this marker. Positive diagnosis is suggested when respiratory and digestive symptoms meet fertility disfunction and "salty kiss" due to sodium--clorure disorders and confirmed by chest X-ray, spirogram, bacteriologic exam of sputum, genetic analysis and positive tests of the pancreatic enzymes and sweat's test. As regards therapeutical solutions, besides antibiotics required in infectious exacerbation, corticotherapy, kinesitherapy and alpha dornasis given in aerosols to improve bronchial mucosa's clearance, also substitutes of pancreatic enzymes and hypercaloric diet are to be considered. In the last two decades, lung transplant appeared to be as an alternative to improve poor prognosis of this disease. Recent studies reported that life expectancy in cystic fibrosis will increase from 28 years in the '90s to 40 years in the next 20 years.
Related Concept Videos
Cystic Fibrosis: Management
Sinus disease and chronic sinusitis...
Cryptococcal Meningitis
Chronic Obstructive Pulmonary Disease-V: Management
Smoking Cessation
Cytomegalovirus Disease
Pulmonary Tuberculosis V
Latent tuberculosis infection occurs when TB bacteria are present in a person's body, but are not causing illness or symptoms. It is not contagious, and preventive treatment is crucial to avoid the progression...
Cystic Fibrosis: Pathogenesis
CF is primarily caused by a genetic mutation in a chromosome 7 gene coding for the cystic fibrosis transmembrane conductance regulator (CFTR) protein. The most common gene mutation leading to CF is the ΔF508 mutation, but...
