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Related Experiment Videos

[Oral disintegrating tablets. A new, modern, solid dosage form].

Graţiela Popa1, Eliza Gafiţanu

  • 1Disciplina de Tehnologie Farmaceutică şi Biofarmacie, Facultatea de Farmacie, Universitatea de Medicină şi Farmacie Gr.T. Popa Iaşi.

Revista Medico-Chirurgicala a Societatii De Medici Si Naturalisti Din Iasi
|February 6, 2004
PubMed
Summary

Orally disintegrating tablets offer improved patient compliance for those with swallowing difficulties. Various manufacturing techniques are enhancing the development of these fast-dissolving drug formulations.

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Area of Science:

  • Pharmaceutical Sciences
  • Drug Delivery Systems
  • Formulation Development

Context:

  • Growing pharmaceutical market interest in orally disintegrating tablets (ODTs).
  • ODTs address challenges faced by specific patient populations, including the elderly and children.
  • Patient preference for ODTs stems from improved swallowing ease compared to conventional solid dosage forms.

Purpose:

  • To review current industrial preparation methods for orally disintegrating tablets.
  • To highlight the significance of ODTs in enhancing patient acceptability and compliance.
  • To discuss the future outlook for fast-dissolving dosage formulations in the pharmaceutical industry.

Summary:

  • Key ODT manufacturing methods include molding, lyophilization, direct compression using soluble excipients, super disintegrants, and effervescent systems.

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  • These techniques facilitate the rapid disintegration of tablets in the oral cavity.
  • The development of ODTs is driven by the need for more convenient and effective drug delivery.

    • Impact:

    • Orally disintegrating tablets have positively impacted the pharmaceutical market by improving patient adherence.
    • Advancements in ODT technology are expected to lead to new drug formulations.
    • The trend towards fast-dissolving formulations signifies a shift towards patient-centric drug design.