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Updated: Aug 29, 2026

Analyzing the Permeability of the Blood-Brain Barrier by Microbial Traversal through Microvascular Endothelial Cells
Published on: February 14, 2020
[Implication of methylglyoxal in diabetes mellitus]
Anca Artenie1, R Artenie, Didona Ungureanu
1Clinica a IV-a Medicală, Spitalul Clinic nr.2 C.I. Parhon Iaşi.
Abstract:
Methylglyoxal (MG) is an early glycation product which is implicated in genesis of diabetic complications either as a direct toxin or as a precursor for advanced glycation end products. It is metabolized via S-D-lactoylglutathione to D-lactate by means of the enzymes glyoxalase I and II, which depend on glutattione as cofactor. MG is highly reactive and can bind to and modify proteins by chemical interaction with cellular proteins, action on energy production, induce free radical generation and cell killing. That way MG play a role in the events of the development of diabetic complications.
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