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Published on: January 28, 2014

Statistical epidemiological screening methods assessing certain biochemical markers

Doina Azoicăi1, L V Boiculese, C Rezuş

  • 1Department of Epidemiology, School of Medicine, University of Medicine and Pharmacy Gr.T. Popa, Iaşi.

Revista Medico-Chirurgicala a Societatii De Medici Si Naturalisti Din Iasi
|February 6, 2004
PubMed

Insights

This study establishes normal serum biochemical marker ranges for cardiovascular disease risk in Iaşi City adults. Mean values for total cholesterol, total lipids, triglycerides, glycemia, and urea were determined in a healthy population sample.

Area of Science:

  • Biochemistry
  • Epidemiology
  • Public Health

Background:

  • Defining normal serum biochemical marker ranges for cardiovascular diseases (CVDs) like total cholesterol (TC), total lipids (TL), triglycerides (TG), glycemia (G), and urea (U) is challenging.
  • Epidemiological studies highlight the difficulty in establishing universally accepted
  • normal
  • values for these predictive CVD markers.

Purpose of the Study:

  • To establish mean and limit values for serum biochemical markers (TC, TL, TG, G, U) in an adult population from Iaşi City.
  • To provide reference values for interpreting CVD risk based on biochemical data in this specific region.
  • To assess the influence of age and sex on these biochemical markers.

Main Methods:

  • Epidemiological screening methodology employed over 5 years, involving 2788 biochemical determinations.
  • Data analysis using the EpiInfo computer program to interpret results.
  • Differentiated analysis of data from apparently healthy individuals (n=2691) and those with diagnosed diabetes mellitus or CVDs (n=97).

Main Results:

  • Mean values in apparently healthy individuals (aged 20-60) were: TC 210 mg%, TL 6.74 g@1000, TG 125.74 mg%, G 0.91 g%, and U 0.34 g%.
  • Significant correlations were observed between age and TC (r=0.38), TG (r=0.26), and G (r=0.23).
  • No significant differences in mean values were found between males and females for any assessed marker (p > 0.05).

Conclusions:

  • The established mean and limit values serve as crucial reference points for CVD risk assessment in the Iaşi City population.
  • These findings will aid clinicians and community health studies in interpreting biochemical marker data more accurately within the regional context.
  • The study underscores the importance of localized epidemiological data for precise health risk evaluation.

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