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Statistical epidemiological screening methods assessing certain biochemical markers.

Doina Azoicăi1, L V Boiculese, C Rezuş

  • 1Department of Epidemiology, School of Medicine, University of Medicine and Pharmacy Gr.T. Popa, Iaşi.

Revista Medico-Chirurgicala a Societatii De Medici Si Naturalisti Din Iasi
|February 6, 2004
PubMed
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This study establishes normal serum biochemical marker ranges for cardiovascular disease risk in Iaşi City adults. Mean values for total cholesterol, total lipids, triglycerides, glycemia, and urea were determined in a healthy population sample.

Area of Science:

  • Biochemistry
  • Epidemiology
  • Public Health

Background:

  • Defining normal serum biochemical marker ranges for cardiovascular diseases (CVDs) like total cholesterol (TC), total lipids (TL), triglycerides (TG), glycemia (G), and urea (U) is challenging.
  • Epidemiological studies highlight the difficulty in establishing universally accepted
  • normal
  • values for these predictive CVD markers.

Purpose of the Study:

  • To establish mean and limit values for serum biochemical markers (TC, TL, TG, G, U) in an adult population from Iaşi City.
  • To provide reference values for interpreting CVD risk based on biochemical data in this specific region.
  • To assess the influence of age and sex on these biochemical markers.

Main Methods:

  • Epidemiological screening methodology employed over 5 years, involving 2788 biochemical determinations.

Related Experiment Videos

  • Data analysis using the EpiInfo computer program to interpret results.
  • Differentiated analysis of data from apparently healthy individuals (n=2691) and those with diagnosed diabetes mellitus or CVDs (n=97).

    • Main Results:

    • Mean values in apparently healthy individuals (aged 20-60) were: TC 210 mg%, TL 6.74 g@1000, TG 125.74 mg%, G 0.91 g%, and U 0.34 g%.
    • Significant correlations were observed between age and TC (r=0.38), TG (r=0.26), and G (r=0.23).
    • No significant differences in mean values were found between males and females for any assessed marker (p > 0.05).

    Conclusions:

    • The established mean and limit values serve as crucial reference points for CVD risk assessment in the Iaşi City population.
    • These findings will aid clinicians and community health studies in interpreting biochemical marker data more accurately within the regional context.
    • The study underscores the importance of localized epidemiological data for precise health risk evaluation.