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[Study of the cardiovascular properties of some new methyl-xanthine derivatives]
Lenuţa Profire1, Gh Dănilă, M Nechifor
1Disciplina de Chimie Farmaceutică, Facultatea de Farmacie, Universitatea de Medicină şi Farmacie Gr.T. Popa Iaşi.
Abstract:
The effects of some new methylxanthine compounds, derivatives of theophylline, theobromine and caffeine with various radicals in 8 position on blood pressure have been studied. Derivatives of theophylline (1,3-dimethyl-xanthine) with various radicals in 8 position have reduced the blood pressure. In the same experimental conditions the theobromine (3,7-dimethyl-xanthine) derivatives haven't modified the blood pressure while the caffeine (1,3,7-trimethyl-xanthine) derivatives have increased the blood pressure values.
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