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Updated: Aug 29, 2026

Testing the Role of Multicopy Plasmids in the Evolution of Antibiotic Resistance
Published on: May 2, 2018
[In vitro antibacterial activity and beta-lactamase stability of meropenem]
Antonia Poiată1, Cristina Tuchiluş, Ioana Bădicuţ
1Facultatea de Farmacie, Disciplina Microbiologie, Universitatea de Medicină şi Farmacie Gr.T. Popa, Iaşi.
Abstract:
The comparative activity of meropenem with that of imipenem, cefotaxime, ceftriaxone and ceftazidime against 856 gram-negative bacilli was studied studied by an agar dilution method. Meropenem and imipenem were high active against tested strains. Resistance to third generation cephalosporins was high for most microorganisms tested. For rapid detection of metallo-beta-lactamase (MBL)-producing gram-negative bacilli a simple disk diffusion test was used. EDTA, FeCl2 and CuCl2 were evaluated as IMP-1 inhibitors. The method is helpful for screening of IMP-1 producers in daily clinical activity.
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