Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Programming of a flexible computer simulation to visualize pharmacokinetic-pharmacodynamic models.

J Lötsch1, G Kobal, G Geisslinger

  • 1Pharmazentrum Frankfurt, Institute of Clinical Pharmacology, Johann Wolfgang Goethe University, Frankfurt, Germany. j.loetsch@em.uni-frankfurt.de

International Journal of Clinical Pharmacology and Therapeutics
|February 6, 2004
PubMed
Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Endocannabinoid analysis in GlucoEXACT plasma: Method validation and sample handling recommendations.

Talanta·2024
Same author

Metabolomic and lipidomic fingerprints in inflammatory skin diseases - Systemic illumination of atopic dermatitis, hidradenitis suppurativa and plaque psoriasis.

Clinical immunology (Orlando, Fla.)·2024
Same author

Pre-analytical sample handling standardization for reliable measurement of metabolites and lipids in LC-MS-based clinical research.

Journal of mass spectrometry and advances in the clinical lab·2023
Same author

Post-mortem changes of prostanoid concentrations in tissues of mice: Impact of fast cervical dislocation and dissection delay.

Prostaglandins & other lipid mediators·2022
Same author

Pre-analytical challenges for the quantification of endocannabinoids in human serum.

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences·2022
Same author

A data science-based analysis of seasonal patterns in outpatient presentations due to olfactory dysfunction.

Rhinology·2019

This study introduces custom computer simulations for teaching pharmacokinetic-pharmacodynamic (PK/PD) models, offering adaptable solutions for complex drug behavior. These interactive simulations enhance learning through intuitive programming and visualization.

Area of Science:

  • Pharmacology
  • Computational Biology
  • Medical Education

Background:

  • Teaching pharmacokinetic-pharmacodynamic (PK/PD) models traditionally relies on static methods.
  • Existing simulation software may lack flexibility for complex or non-standard PK/PD models.

Purpose of the Study:

  • To propose and describe the programming of educational PK/PD computer simulations as an adaptable alternative to pre-built software.
  • To enhance the effectiveness of teaching PK/PD models through interactive computer simulations.

Main Methods:

  • Utilized the LabVIEW programming environment for simplified, intuitive simulation development.
  • Implemented continuously repeating loops for high interactivity and flexible user input.
  • Demonstrated programming with a 2-compartment PK model and presented examples of PK/PD and multi-compartmental models.

Related Experiment Videos

Main Results:

  • Developed adaptable PK/PD simulations with intuitive user interfaces for visualizing drug concentration and effect time courses.
  • Achieved high interactivity, allowing flexible user input and dynamic simulation behavior.
  • Provided examples including multi-compartmental models for morphine kinetics and effects.

Conclusions:

  • Programming educational PK/PD simulations in LabVIEW offers an adaptable and interactive approach to clinical pharmacology teaching.
  • This method is suitable for pharmacokineticists who occasionally program, enabling the creation of flexible, interactive simulation algorithms.
  • The developed programs are available for download, facilitating broader adoption in PK/PD education.