Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Photoaging and oxidative stress.

Chikako Nishigori1, Yukari Hattori, Yaeno Arima

  • 1Department of Dermatology, Graduate School of Medicine, Kobe University, Kobe, Japan. chikako@med.kobe-u.ac.jp

Experimental Dermatology
|February 6, 2004
PubMed
Summary

Photoaging, distinct from natural aging, is caused by ultraviolet radiation (UVR) and oxidative stress. Markers like 8-OHdG in UV-exposed skin confirm this link, highlighting UVR

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Pro-inflammatory roles of ultraviolet radiation in cutaneous photocarcinogenesis.

Photochemistry and photobiology·2026
Same author

Disrupted epigenetic regulation in human senile lentigines revealed by characterizing gene expression and DNA methylation alterations.

Clinical epigenetics·2026
Same author

Clinical Practice Guidelines for the Management of Porphyrias in Japan: Secondary Publication (English Translation).

The Journal of dermatology·2026
Same author

Whole-genome sequencing reveals rare and structural variants contributing to psoriasis and identifies CERCAM as a risk gene.

Cell genomics·2025
Same author

Contribution of germline and somatic mutations to risk of neuromyelitis optica spectrum disorder.

Cell genomics·2025
Same author

Melatonin mitigates UV-induced tumorigenesis and suppresses hearing function deterioration in Xpa-deficient mice.

Journal of dermatological science·2025

Area of Science:

  • Dermatology and Cellular Biology
  • Investigating the molecular mechanisms of skin aging

Background:

  • Photoaging presents distinct clinical and histological features compared to chronological aging.
  • Ultraviolet radiation (UVR) is a primary environmental factor contributing to skin aging.
  • Oxidative stress is hypothesized to be a key mediator in the development of photoaging.

Purpose of the Study:

  • To review and discuss the pathophysiology of skin photoaging induced by chronic UVR exposure.
  • To emphasize the critical role of oxidative stress in UV-induced skin damage.
  • To explore the molecular markers associated with photoaging.

Main Methods:

  • Review of existing scientific literature on photoaging and UVR.
  • Analysis of histological and molecular evidence in UV-exposed skin specimens.
  • Focus on the biochemical pathways involving oxidative stress.

Main Results:

  • Evidence supports the theory that UVR generates oxidative stress, leading to photoaging.
  • Specific biomarkers of oxidative damage, including 8-OHdG and modified proteins (4-hydroxy-2-nonenal, 3-L-nitro-tyrosine, N(-epsilon)(carboxymethyl)lysine), are present in UV-exposed skin.
  • Chronic inflammation is identified as a component of UVR-induced photoaging pathophysiology.

Conclusions:

  • Oxidative stress is a central mechanism in the development of photoaging.
  • The presence of specific oxidative damage markers validates the link between UVR and skin aging.
  • Understanding these pathways is crucial for developing preventative and therapeutic strategies against photoaging.

Related Experiment Videos