[Sex hormone balance in prostate cancer]

In cancer of the prostatic gland of stage II--III in males, 50--60 years, a reduced gonadial endocrine function is observed, that is manifested in a considerably reduced excretion of testosterone and estrogen. Because of the different rate of reduction in the testosterone and estrogen excretion in patients 50--69 years of age, one may observe the state of relative and in 70--80 years old patients--absolute hyperandrogenization of the organism, which is likely to be an unfavorable factor, taking into account the property of testosterone metabolites (dihydrotestosterone in particular) to enhance proliferative processes in the prostatic gland.