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Updated: Aug 29, 2026

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10:09

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Published on: January 7, 2019

Conditional animal models: a strategy to define when oncogenes will be effective targets to treat cancer

Sylvie Giuriato1, Karen Rabin, Alice C Fan

  • 1Division of Oncology, Stanford University, CCSR 1105, 269 Campus Drive, Stanford, CA 94305-5151, USA.

Seminars in Cancer Biology
|February 6, 2004
PubMed

Insights

Mouse cancer models are crucial for understanding cancer

Area of Science:

  • Oncology
  • Genetics
  • Translational Research

Background:

  • Mouse models are essential for cancer research.
  • They help investigate the molecular causes of cancer.
  • These models are used to test new cancer treatments.

Purpose of the Study:

  • To highlight the utility of mouse cancer models.
  • To demonstrate the effectiveness of targeting oncogenes.
  • To identify potential therapeutic targets for human cancers.

Main Methods:

  • Utilizing conditional gene induction or knockout strategies in mice.
  • Engineering mice for tissue-specific gene manipulation.
  • Studying the impact of targeted oncogene inactivation on tumor regression.

Main Results:

  • Targeted inactivation of specific oncogenes can lead to sustained tumor regression.
  • Engineered mouse models effectively demonstrate therapeutic potential.
  • This methodology aids in dissecting cancer's molecular basis.

Conclusions:

  • Mouse models are powerful platforms for preclinical therapeutic evaluation.
  • Conditional gene manipulation in mice aids in identifying effective cancer targets.
  • This research defines genes for targeted cancer therapy development.

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