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Cardiovascular events in diabetic and nondiabetic adults with or without history of myocardial infarction
Chong Do Lee1, Aaron R Folsom, James S Pankow
1Department of Sports and Exercise Sciences, West Texas A&M University, Canyon, Tex, USA.
Circulation
|February 6, 2004
Summary
Diabetic patients without a history of myocardial infarction (MI) face lower risks of coronary heart disease (CHD) events and cardiovascular disease (CVD) mortality than those with MI. However, stroke risk is comparable between these groups.
Area of Science:
- Cardiovascular Medicine
- Diabetes Research
- Epidemiology
Background:
- The comparative cardiovascular risk between diabetic patients without myocardial infarction (MI) and nondiabetic patients with a history of MI is debated.
- Understanding these risks is crucial for targeted prevention strategies.
Purpose of the Study:
- To compare the risks of coronary heart disease (CHD) events, stroke, and cardiovascular disease (CVD) mortality.
- To evaluate these risks in diabetic versus nondiabetic individuals, with and without a history of MI.
Main Methods:
- Analysis of 13,790 participants (ages 45-64) from the Atherosclerosis Risk in Communities study (1987-1989).
- Follow-up for an average of 9 years, recording fatal/nonfatal CHD, MI, stroke, and CVD mortality.
- Statistical adjustments for age, sex, race, field center, and baseline risk factors.
Main Results:
- Nondiabetic patients with a history of MI had 1.9 times higher risk of fatal/nonfatal MI compared to diabetic patients without MI.
- Nondiabetic patients with MI also had 1.8 times higher risk of CVD mortality.
- Stroke risk and carotid artery wall thickness were similar between diabetic patients without MI and nondiabetic patients with MI.
Conclusions:
- Diabetic patients without a history of MI have a lower risk of CHD events and CVD mortality than nondiabetic patients with a history of MI.
- Stroke risk is similar between these two patient groups.
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