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Area of Science:

  • Gastroenterology
  • Molecular Biology
  • Oncology

Background:

  • Apc(min) mice are a model for studying intestinal polyposis.
  • Peroxisome proliferator-activated receptor-delta (PPAR-delta) is a nuclear receptor with known roles in metabolism and inflammation.

Purpose of the Study:

  • To investigate the role of PPAR-delta in intestinal adenoma development.
  • To determine the effect of a selective PPAR-delta agonist on polyp growth in Apc(min) mice.

Main Methods:

  • Treatment of Apc(min) mice with GW501516, a selective synthetic agonist of PPAR-delta.
  • Quantification of intestinal polyp number and size.

Main Results:

  • PPAR-delta activation led to a significant increase in both the number and size of intestinal polyps.
  • A fivefold increase in polyps larger than 2 mm was observed in treated mice.
  • The most pronounced effect was on polyp size, indicating a role in adenoma growth.

Conclusions:

  • PPAR-delta signaling is implicated in the regulation of intestinal adenoma growth.
  • Targeting PPAR-delta may represent a potential therapeutic strategy for intestinal polyposis.