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Solid-phase Synthesis of [4.4] Spirocyclic Oximes
Published on: February 6, 2019
Solid-phase strategies for the design and synthesis of heterocyclic molecules of medicinal interest
1Central Drug Research Institute, Medicinal Chemistry Division, Lucknow-226 001, India. bijoy_kundu@yahoo.com
Abstract:
Recently, there has been a wealth of reports concerning the polymer-supported traceless synthesis of heterocyclic structures of medicinal interest. In 2002, important advances included the continued use of cyclative cleavage strategies to obtain novel heterocyclic structures with high chemical diversity. In addition to these strategies, several reports based on a novel approach involving the use of common combinatorial scaffolds for the generation of a variety of heterocyclic structures have also appeared. This review covers the application of these two approaches to a wide array of compounds based on azoles quinazolines, indoles, pyridines, isoxazolines, piperazines and pyrroles.
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