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Updated: Aug 29, 2026

In Vivo Augmentation of Gut-Homing Regulatory T Cell Induction
Published on: January 22, 2020
The Th1 immune pathway as a therapeutic target in Crohn's disease
Giorgos Bamias1, Kazuhiko Sugawara, Cristiano Pagnini
1Digestive Health Center of Excellence, University of Virginia Health System, PO Box 800708, Charlottesville, VA 22908, USA.
Abstract:
Crohn's disease (CD) is a chronic inflammatory condition of the gastrointestinal tract, characterized by overactive T-helper (Th)1-mediated responses towards resident bacterial flora in genetically susceptible individuals. Biotechnological methodology has allowed the development of therapeutic compounds that specifically target single, well-defined pathways, thereby inhibiting abnormal Th1 polarization. These therapies include antibody-based, as well as nucleic-acid related approaches that target various pro-inflammatory cytokines, as well as intracellular signaling pathways. This review summarizes treatments already in clinical use and discusses novel targets that offer additional therapeutic opportunities in the management of CD.
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