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[Idiopathic primary pulmonary hemosiderosis: treatment with cyclophosphamide and prednisone]

S E Viera1, A A Osmo, J P Lotufo

  • 1Divisão de Pediatria, Hospital Universitario da USP, São Paulo, SP.

Jornal De Pediatria
|November 1, 1996
PubMed

Insights

Idiopathic pulmonary hemosiderosis in a child showed poor response to prednisone and chloroquine. Adding cyclophosphamide led to remission, suggesting this combination may benefit selected cases.

Area of Science:

  • Pediatric Pulmonology
  • Rare Diseases
  • Immunosuppressive Therapy

Context:

  • Idiopathic pulmonary hemosiderosis (IPH) is a rare condition causing lung bleeding.
  • Pediatric IPH cases often present diagnostic and therapeutic challenges.

Purpose:

  • To report a pediatric case of idiopathic pulmonary hemosiderosis.
  • To evaluate the efficacy of a treatment regimen including cyclophosphamide.

Summary:

  • A five-year-old child with IPH initially responded poorly to prednisone and chloroquine.
  • Combination therapy with prednisone and cyclophosphamide induced clinical and radiological remission.
  • The patient remained in remission for one year after discontinuing medication.

Impact:

  • This case suggests cyclophosphamide and prednisone may be a viable treatment for selected pediatric IPH patients.
  • Highlights the potential for successful management of refractory IPH with immunosuppressive agents.

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