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Updated: Oct 14, 2026

Differential Effects of Lipid-lowering Drugs in Modulating Morphology of Cholesterol Particles
Published on: November 10, 2017
[Lowering increased cholesterol--prolonging life?]
1Abteilung für Kardiologie, Universität Frankfurt a. M.
Abstract:
Epidemiologic surveys reveal a positive correlation between serum cholesterol levels and the incidence of coronary artery disease. Intervention trials demonstrated that a reduction of serum cholesterol by 1% results in a decrease of coronary non-fatal events by 2%. Fatal coronary events remain almost uninfluenced. On the other side, several intervention trials showed an excess mortality from non-cardiac causes in the therapy groups (i.e. malignant tumors, suicides, accidents). Thus, until now no prolongation of life expectancy could be verified by cholesterol lowering measures.
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