Related Experiment Video
Updated: Aug 11, 2026

Selection of Plasmodium falciparum Parasites for Cytoadhesion to Human Brain Endothelial Cells
Published on: January 3, 2012
Cerebral Malaria
1Departments of Neurology and Epidemiology, Michigan State University, #138 Service Road, A217, East Lansing, MI 48824, USA. gretchen.birbeck@ht.msu.edu
Abstract:
Successful management of cerebral malaria requires rapid diagnosis, initiation of appropriate antimalarial agents, and aggressive supportive care. The antimalarial used will depend on drug availability, with many of the most effective agents not routinely available in the US. The use of technologically advanced diagnostic studies, such as electroencephalogram, that are generally not available in malaria-endemic regions may aid in management. But other tests, such as advanced neuroimaging, may offer limited guidance because there are little data indicating the best management of conditions, such as increased intracranial pressure, focal edema, and microhemorrhages. Close clinical assessments and rapid initiation of proven therapies should be the focus of care, even when advanced resources are available. Given the mortality of this condition and the long-term neurologic morbidity seen in survivors, adjunctive therapies are clearly needed to improve patient outcomes. Until more data are available, much of the management of cerebral malaria will continue to be based on anecdote rather than evidence.
More Related Videos
12:48Isolation and Analysis of Brain-sequestered Leukocytes from Plasmodium berghei ANKA-infected Mice
Published on: January 2, 2013
09:04In Vivo Tracking of Edema Development and Microvascular Pathology in a Model of Experimental Cerebral Malaria Using Magnetic Resonance Imaging
Published on: June 8, 2017
Related Concept Videos
Cryptococcal Meningitis
Malaria
Bacterial Meningitis I: Introduction
Encephalitis l: Introduction
Cerebral Edema l: Introduction
Cerebral Edema ll: Pathophysiology