Botulinum toxin in the lower one third of the face

The use of botulinum toxin (BTX) in the lower one third of the face has rapidly become one of the most popular ways to rejuvenate the face, due to the effectiveness of BTX in this area and the lack of major side effects. It is recommended that physicians planning on treating patients in this area of the face first have extensive experience treating the more traditional areas, such as the forehead, glabella, or crow's feet, because the inferior one third of the face has many co-dependent and interdigitating (interrelated) muscles that are very sensitive and readily affected by minimal amounts of BTX. We prefer to reconstitute a 100-U vial of Botox(R) with 1-2.5 mL of saline solution because some of the muscles in this area of the face are very sensitive to diffusion of the toxin and will be weakened beyond the area originally planned for treatment.