Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Functional imaging during covert auditory attention in multiple sclerosis.

Michael P Santa Maria1, Ralph H B Benedict, Rohit Bakshi

  • 1Department of Neurology, School of Medicine, State University of New York at Buffalo, Buffalo General Hospital, Neurology, Suite D-6 Buffalo, 100 High Street, 14203, USA.

Journal of the Neurological Sciences
|February 5, 2004
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Exploring the natural age cutoff point for primary-progressive multiple sclerosis therapy.

Expert review of neurotherapeutics·2025
Same author

Neuroimaging phenotype characterization of early aggressive and late severe multiple sclerosis: a case-control study.

Brain communications·2025
Same author

Verona validation of the DAAE score, a tool for estimating risk of clinical disease progression in people with multiple sclerosis.

Multiple sclerosis and related disorders·2025
Same author

Personality traits and disease worsening in multiple sclerosis: Associations with neuroticism and conscientiousness.

Multiple sclerosis and related disorders·2025
Same author

Safety and tolerability of conversion to siponimod from other disease-modifying therapies in patients with advancing forms of relapsing MS: Results from the EXCHANGE study.

Multiple sclerosis (Houndmills, Basingstoke, England)·2025
Same author

Standardized Definition of Progression Independent of Relapse Activity (PIRA) in Relapsing-Remitting Multiple Sclerosis.

JAMA neurology·2025
Same journal

Distinguishing drug-target effects from natural lipid variation and incorporating imaging outcomes in Mendelian randomisation studies of multiple sclerosis.

Journal of the neurological sciences·2026
Same journal

Long-term social cognitive impairment after ischemic stroke: Frequency and association with lesion volume and location in an exploratory pilot study.

Journal of the neurological sciences·2026
Same journal

Subjective cognitive decline among U.S. Cancer survivors, 2017-2024: Prevalence, cancer-specific patterns, and associated factors.

Journal of the neurological sciences·2026
Same journal

Comment on "Comparative impact of mental and cardiovascular comorbidities on adverse outcomes in people with MS".

Journal of the neurological sciences·2026
Same journal

Comment on "Efficacy and safety of conventional immunosuppressant therapies in elderly patients with Neuromyelitis optica spectrum disorder: A target trial emulation study".

Journal of the neurological sciences·2026
Same journal

Increasing incidence of varicella-zoster virus meningitis in Japan, 2011-2022.

Journal of the neurological sciences·2026
See all related articles

Multiple sclerosis (MS) patients show brain reorganization during auditory attention tasks. This involves reduced frontal brain activity and increased auditory cortex activation, indicating altered neural pathways.

Area of Science:

  • Neuroscience
  • Neurology
  • Cognitive Science

Background:

  • Multiple sclerosis (MS) is associated with brain reorganization for visual and motor tasks.
  • The neural basis of attention in MS, particularly auditory attention, remains less understood.

Purpose of the Study:

  • To investigate cerebral activity patterns in MS patients during an auditory covert attention (CA) task.
  • To compare brain activation in MS patients with that of normal subjects during the same task.

Main Methods:

  • Positron emission tomography (PET) was used to identify sites of cerebral activity.
  • 16 patients with MS performed an auditory CA task.

Main Results:

  • MS patients showed significantly reduced activation in the anterior cingulate cortex (ACC) compared to normal subjects.

Related Experiment Videos

  • Increased activity was observed in the superior temporal cortex (auditory association cortex) in MS patients.
  • Findings suggest decreased transmission along white matter tracts connecting frontal and auditory regions.

    • Conclusions:

    • The study demonstrates cingulate hypoactivity in MS patients during auditory attention.
    • Evidence of cerebral reorganization, with a shift towards sensory/perceptual areas, was observed in MS.
    • Altered brain activity patterns in MS may reflect compensatory mechanisms or disease-related changes.