Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Remodeling the blood coagulation cascade.

Maureane Hoffman1

  • 1Department of Pathology, Duke University Medical Center and Durham VA Medical Center, Durham, NC 27705, USA. maureane.hoffman@med.va.gov

Journal of Thrombosis and Thrombolysis
|February 5, 2004
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The kinetics and interplay of thrombin inhibition by 4 plasma proteinase inhibitors.

Blood vessels, thrombosis & hemostasis·2025
Same author

True anticoagulation safety cannot be achieved without better anticoagulants.

BMJ open quality·2025
Same author

Recombinant factor VIIa: new insights into the mechanism of action through product innovation.

Research and practice in thrombosis and haemostasis·2025
Same author

Modelling the effects of 4-factor prothrombin complex concentrate for the management of factor Xa-associated bleeding.

PloS one·2024
Same author

Ultrasoft platelet-like particles stop bleeding in rodent and porcine models of trauma.

Science translational medicine·2024
Same author

Emicizumab promotes factor Xa generation on endothelial cells.

Journal of thrombosis and haemostasis : JTH·2024

The traditional coagulation cascade model has limitations. A cell-based hemostasis model better explains bleeding disorders and thrombosis by highlighting parallel pathways on distinct cell surfaces.

Area of Science:

  • Biochemistry
  • Hematology
  • Physiology

Background:

  • The conventional coagulation cascade model inadequately explains in vivo hemostasis.
  • It fails to account for bleeding in conditions like hemophilia despite an intact extrinsic pathway.

Purpose of the Study:

  • To address the limitations of the coagulation cascade model.
  • To propose a refined model of hemostasis that better reflects in vivo conditions.

Main Methods:

  • Critically evaluating the existing coagulation cascade model.
  • Developing a cell-based model of hemostasis incorporating cellular interactions.
  • Analyzing the roles of the intrinsic and extrinsic pathways within the new model.

Main Results:

Related Experiment Videos

  • The cell-based model provides a more accurate explanation for bleeding and thrombosis.
  • It demonstrates that the intrinsic and extrinsic pathways are not redundant but function in parallel.
  • Localization of procoagulant reactions on cell surfaces is key to controlling coagulation.

Conclusions:

  • A cell-based model offers superior insight into in vivo hemostasis compared to the cascade model.
  • Understanding cell surface interactions is crucial for explaining coagulation dynamics.
  • The intrinsic and extrinsic pathways play distinct, parallel roles in hemostasis.