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Simultaneous expression of COX-2 and mPGES-1 in mouse gastrointestinal hamartomas
1Department of Pharmacology, Kyoto University Graduate School of Medicine, Kyoto 606-8501, Japan.
Abstract:
Cyclo-oxygenase (COX)-2 is induced in various types of cancer tissues. Here, we demonstrate stromal expression of both COX-2 and microsomal prostaglandin E(2) synthase (mPGES)-1 in gastrointestinal hamartomas developed in Lkb1(+/-), Smad4(+/-) and Cdx2(+/-)mice. These results suggest that PGE(2) produced by COX-2 and mPGES-1 plays an important role in hamartoma development regardless of the mutated genes causing hamartomas.
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