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Positive antinuclear antibody in atopic dermatitis
Y Taniguchi1, A Yamakami, T Sakamoto
1Department of Dermatology, Mie University School of Medicine, Tsu, Japan.
Acta Dermato-Venereologica. Supplementum
|January 1, 1992
Summary
Antinuclear antibody (ANA) detection in atopic dermatitis (AD) patients revealed positive results in a significant portion. Facial lesions and disease severity correlated with ANA presence and titer, respectively.
Area of Science:
- Immunology
- Dermatology
- Clinical Chemistry
Background:
- Atopic dermatitis (AD) is a chronic inflammatory skin condition.
- Antinuclear antibodies (ANA) are associated with various autoimmune diseases.
- The prevalence and significance of ANA in AD are not fully understood.
Purpose of the Study:
- To investigate the presence and patterns of antinuclear antibodies (ANA) in patients with atopic dermatitis (AD).
- To explore potential correlations between ANA status and clinical features of AD, such as facial lesions and disease severity.
Main Methods:
- Serum samples from AD patients were analyzed using two distinct immunofluorescence methods on HEp-2 cells.
- Method 1 utilized FITC-conjugated polyvalent immunoglobulins for ANA detection.
- Method 2 employed FITC-conjugated anti-IgG antibodies for ANA detection.
Main Results:
- Positive ANA results were observed in 34.0% of 47 AD patients using method 1.
- A positive ANA rate of 26.3% was found in 57 AD patients examined with method 2.
- A tendency towards positive ANA was noted in AD patients with facial lesions.
- Severe AD cases were associated with higher titers of ANA.
Conclusions:
- ANA detection is relevant in the immunological profile of atopic dermatitis patients.
- The presence of ANA may be linked to specific clinical manifestations like facial involvement.
- Higher ANA titers correlate with increased disease severity in atopic dermatitis.