Related Experiment Video

Updated: Aug 29, 2026

Measuring Volatile and Non-volatile Antifungal Activity of Biocontrol Products
06:47

Measuring Volatile and Non-volatile Antifungal Activity of Biocontrol Products

Published on: December 5, 2020

The efficacy and safety of terbinafine in children

A K Gupta1, A Adamiak, E A Cooper

  • 1Division of Dermatology, Department of Medicine, Sunnybrook and Women's College Health Sciences Center (Sunnybrook site) and the University of Toronto, Toronto, Canada. agupta@execulink.com

Journal of the European Academy of Dermatology and Venereology : JEADV
|February 6, 2004
PubMed

Insights

Terbinafine is an effective and safe antifungal treatment for pediatric superficial fungal infections like tinea capitis. Short-duration terbinafine therapy improves compliance and offers a cost-effective solution for children.

Area of Science:

  • Dermatology
  • Mycology
  • Pediatrics

Background:

  • Terbinafine, an allylamine antifungal, is established for adult superficial and deep mycotic infections.
  • Growing evidence supports terbinafine use in pediatric superficial fungal infections, especially tinea capitis.

Purpose of the Study:

  • To evaluate the efficacy and safety of terbinafine in treating pediatric superficial fungal infections.
  • To assess terbinafine's suitability for pediatric tinea capitis treatment compared to existing standards.

Main Methods:

  • Review of available data on terbinafine use in pediatric populations.
  • Analysis of treatment regimens, efficacy rates, and adverse event profiles.

Main Results:

  • Terbinafine demonstrates effectiveness and safety in children with superficial fungal infections.
  • Short-duration terbinafine regimens enhance compliance and cost-effectiveness for tinea capitis.
  • Efficacy rates for Trichophyton tinea capitis are favorable with shorter terbinafine courses than griseofulvin.

Conclusions:

  • Terbinafine is a preferred treatment for pediatric superficial fungal infections, including tinea capitis.
  • The safety profile in children mirrors that in adults, with minimal adverse effects.
  • Evidence supports terbinafine's role in improving pediatric antifungal treatment outcomes.

More Related Videos

Reduced Itraconazole Concentration and Durations Are Successful in Treating Batrachochytrium dendrobatidis Infection in Amphibians06:49

Reduced Itraconazole Concentration and Durations Are Successful in Treating Batrachochytrium dendrobatidis Infection in Amphibians

Published on: March 14, 2014

Related Concept Videos

Acne Infection01:27

Acne Infection

Acne is a multifactorial skin condition primarily affecting adolescents and young adults, with a global prevalence estimated to exceed 75% in this demographic. The condition is characterized by the formation of comedones (blackheads and whiteheads), papules, pustules, nodules, and, in severe cases, cysts, particularly in areas rich in sebaceous glands such as the face, neck, chest, and back. The pathogenesis involves increased sebum production, follicular hyperkeratinization, colonization by...
Antiprotozoal Agents01:21

Antiprotozoal Agents

Leishmaniasis is a widespread parasitic disease caused by several Leishmania species. It affects millions of people each year and remains a major public health problem in endemic regions. First-line treatment relies on pentavalent antimonials, including meglumine antimoniate and sodium stibogluconate. Even so, how these drugs work has not been fully clear, especially their interaction with parasite-specific biochemical pathways. One key target is trypanothione reductase (TR), an enzyme that...
Antifungal Agents01:15

Antifungal Agents

Amphotericin B is a broad-spectrum antifungal agent that exploits structural differences between fungal and mammalian cell membranes. Its amphipathic structure—featuring a hydrophobic polyene-lactone ring and a hydrophilic region containing mycosamine and carboxylic acid groups—enables selective binding to ergosterol, a sterol predominantly found in fungal plasma membranes. This selective interaction underlies the drug’s antifungal activity, although weak binding to cholesterol contributes to...
Teratogenicity01:07

Teratogenicity

The ability of a drug to produce structural deformations and functional abnormalities in the developing embryo or the fetus is called teratogenicity, and the drug producing this effect is known as a teratogen. Teratogenic effects include stillbirth, miscarriage, intrauterine growth restriction, and neurocognitive delay. A teratogen may affect the embryo at different stages of development, which is important in determining the type and extent of the damage. During blastocyst formation, the early...
Antimicrobial Effectiveness01:28

Antimicrobial Effectiveness

The effectiveness of antimicrobial agents depends on various factors influencing their ability to eliminate microbial populations. Larger microbial populations require more time for complete eradication, emphasizing the importance of population size analysis when evaluating antimicrobial efficacy.Microbial resistance to antimicrobial agents varies significantly. Highly resilient microorganisms include endospores, gram-negative bacteria, and non-enveloped viruses, while prions are exceptionally...
Anthelminthic Agents01:15

Anthelminthic Agents

Anthelmintic drugs differ significantly from antiparasitic therapies targeting protozoa, primarily due to differences in parasite biology. Whereas most protozoal treatments act on proliferating cells, anthelmintics are typically directed against mature, nonproliferative helminths. The therapeutic approach considers the helminth's reliance on neuromuscular coordination, glucose metabolism, and microtubular integrity for survival, reproduction, and localization within the host. Most anthelmintics...