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Rheumatoid nodulosis: report of two cases.

M T Bordel Gómez1, A Mariscal Polo, A Miranda Romero

  • 1C/Velardes 10, 6o D, 47002-Valladolid, Spain.

Journal of the European Academy of Dermatology and Venereology : JEADV
|February 6, 2004
PubMed
Summary
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This study highlights two patients with rheumatoid nodulosis, a condition causing subcutaneous nodules and palindromic rheumatism. Diagnosis was confirmed via biopsy, excluding rheumatoid arthritis.

Area of Science:

  • Rheumatology
  • Dermatopathology

Background:

  • Rheumatoid nodulosis is a rare condition characterized by subcutaneous nodules.
  • It can present with palindromic rheumatism, mimicking other inflammatory arthropathies.

Observation:

  • Two patients presented with chronic, painless subcutaneous nodules on fingers and elbows.
  • They experienced frequent palindromic rheumatism attacks without signs of arthritis or systemic disease.
  • Histopathology confirmed rheumatoid nodules and transepidermal fibrinoid elimination in one case.

Findings:

  • Biopsies confirmed rheumatoid nodules in both patients.
  • Diagnostic criteria for rheumatoid nodulosis were met, including multiple nodules, palindromic rheumatism, and negative rheumatoid factor.
  • Radiographs and serological tests for rheumatoid arthritis were negative.

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Implications:

  • This case series emphasizes the importance of biopsy for diagnosing rheumatoid nodulosis.
  • It differentiates this condition from rheumatoid arthritis, particularly in seronegative patients.
  • Understanding rheumatoid nodulosis aids in appropriate patient management and treatment strategies.