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[Transitional CK19 positive cells-a new possible marker of hepatic precancerous lesion]
Yu Chen1, Zhong-ping Duan, Bao-en Wang
1Beijing You'an Hospital, Beijing 100050, China.
Objective:
To investigate the relationship between Transitional CK19 positive cells and hepatic precancerous lesion in chronic hepatitis B patients.
Methods:
We observed the expression of CK19 in liver tissue of chronic hepatitis B patients by LSAB immunohistochemical staining, and examined serum AFP and ultrasonography one time per 3 months for one year.
Results:
We observed a population of CK19 positive cells-with size and structure between those of human oval cells and mature hepatocytes-that usually occurred along with oval-cell proliferation. It was suggested that these transitional cells may partly account for the elevation of serum AFP. One patient occurred hepatic carcinoma, another patient had low-echogenic nodules in liver parenchyma within the 1 year follow-up period.
Conclusion:
Transitional CK19 positive cells could be regarded as a new possible pathological marker of hepatic precancerous lesion.
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