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Related Experiment Videos

[Does selective digestive decontamination prevent nosocomial infections?].

F Leclerc1, O Noizet

  • 1Service de réanimation pédiatrique, hôpital Jeanne-de-Flandre, CHU de Lille, France. fleclerc@chru-lille.fr

Archives De Pediatrie : Organe Officiel De La Societe Francaise De Pediatrie
|February 6, 2004
PubMed
Summary

Selective digestive decontamination (SDD) can prevent nosocomial infections and antibiotic resistance in pediatric intensive care units. This strategy, involving topical antibiotics and hygiene, shows promise despite limited pediatric studies.

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Area of Science:

  • Infectious Diseases
  • Critical Care Medicine
  • Microbiology

Context:

  • Nosocomial infections are a major concern in pediatric intensive care and hematological units, increasing mortality, morbidity, and healthcare costs.
  • Selective Digestive Decontamination (SDD) is a strategy involving topical antibiotics, parenteral antibiotics, hand hygiene, and surveillance cultures to combat these infections.
  • While effective in adults, evidence for SDD in children is limited due to small sample sizes and methodological issues.

Purpose:

  • To evaluate the effectiveness and safety of Selective Digestive Decontamination (SDD) in pediatric intensive care settings.
  • To address the limited data on SDD in children and its potential to prevent both infections and antibiotic resistance.
  • To identify patient and unit factors influencing the import of resistant bacteria into intensive care units.

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Summary:

  • SDD involves topical antibiotics, short-term parenteral antibiotics, hand hygiene, and surveillance cultures.
  • In adults, SDD reduces lower airway infections and mortality, but concerns exist regarding antibiotic resistance.
  • Limited pediatric studies suggest SDD may prevent infections and resistance, with many children importing resistant strains upon admission.

Impact:

  • SDD has the potential to significantly reduce healthcare-associated infections and associated costs in pediatric intensive care.
  • Addressing the emergence of antibiotic-resistant bacteria is crucial, and SDD may offer a solution in specific pediatric populations.
  • Optimizing SDD protocols requires careful patient and unit selection, alongside robust surveillance and antibiotic stewardship.