Active surveillance: towards a new paradigm in the management of early prostate cancer
- 1Institute of Cancer Research and Royal Marsden Hospital, Sutton, Surrey, UK. cparker@icr.ac.uk
- 0Institute of Cancer Research and Royal Marsden Hospital, Sutton, Surrey, UK. cparker@icr.ac.uk
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View abstract on PubMed
Summary
This summary is machine-generated.Active surveillance for prostate cancer involves monitoring patients with favorable tumors, avoiding unnecessary curative treatments. This strategy aims to personalize therapy by identifying disease progression through PSA levels and biopsies.
Area Of Science
- Oncology
- Urology
- Cancer Research
Background
- Prostate cancer is often curable but frequently does not require aggressive treatment.
- Active surveillance offers a personalized approach to managing prostate cancer.
Purpose Of The Study
- To individualize prostate cancer therapy by selecting patients for curative treatment.
- To identify markers of prostate cancer behavior through active surveillance.
Main Methods
- Close monitoring of patients with favorable tumor characteristics.
- Utilizing serum prostate-specific antigen (PSA) concentrations and repeat prostate biopsies for assessment.
- Defining disease progression by PSA doubling time and repeat biopsy "upgrading".
Main Results
- Active surveillance allows for careful selection of patients needing curative therapy.
- Identifies opportunities to discover novel prostate cancer biomarkers.
- Provides data for refining treatment paradigms for early-stage prostate cancer.
Conclusions
- Active surveillance enables personalized prostate cancer management.
- Biomarker discovery can improve clinical decision-making and therapeutic targets.
- This approach may shift treatment from eradication to altering disease natural history.
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