Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

Evolution of Staphylococcus aureus by large chromosomal replacements.

D Ashley Robinson¹, Mark C Enright

¹Department of Biology and Biochemistry, University of Bath, Bath BA2 7AY, United Kingdom.

Journal of Bacteriology

|February 6, 2004

Summary

This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Clinical severity-dependent virulence of <i>Staphylococcus aureus</i> from human diabetic foot ulcers drives impaired wound healing in a diabetic murine model.

Frontiers in cellular and infection microbiology·2026

Same author

From Lake Victoria to the Tap: Antibiotic Resistance and Pathogenic Contamination of Kisumu City Water Supply and Wastewater Network.

Tropical medicine & international health : TM & IH·2026

Same author

Whole genome sequencing and phylogenetic analysis to examine acquisition of Escherichia coli clones during international travel.

Diagnostic microbiology and infectious disease·2025

Same author

Variants and vaccines impact nasal immunity over three waves of SARS-CoV-2.

Nature immunology·2025

Same author

Evolution and spread of <i>Xanthomonas citri</i> subsp. <i>citri</i> in the São Paulo, Brazil, citrus belt inferred from 758 novel genomes.

Microbial genomics·2025

Same author

Ultrastructural, metabolic and genetic characteristics of determinants facilitating the acquisition of macrolide resistance by Streptococcus pneumoniae.

Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy·2024

Large-scale bacterial chromosomal replacements, unprecedented in nature, were discovered in Staphylococcus aureus lineages. These significant genetic events, involving hundreds of kilobases, reshape our understanding of bacterial evolution.

Area of Science:

Microbiology
Bacterial Genetics
Evolutionary Biology

Background:

Bacterial chromosomal replacements are typically small or involve mobile genetic elements.
Previous in vitro studies showed large-scale replacements, but natural occurrences were limited.

Purpose of the Study:

To investigate the extent and nature of chromosomal replacements in Staphylococcus aureus.
To determine if large-scale chromosomal replacements occur naturally in bacteria.

Main Methods:

Comparative genomic analysis of Staphylococcus aureus lineages.
Identification and characterization of large chromosomal replacement events.

Main Results:

Two Staphylococcus aureus lineages, including a methicillin-resistant strain, originated from single chromosomal replacements of approximately 244 kb and 557 kb.

Related Experiment Videos

These replacements represent 10% and 20% of the bacterial chromosome, respectively.

No involvement of mobile genetic elements was observed in these large replacements.

Conclusions:

Large-scale chromosomal replacements are a natural phenomenon in Staphylococcus aureus.
These unprecedented replacements have significant implications for bacterial evolution and adaptation.
The unique structure of these replacements challenges existing models of bacterial genetic exchange.