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[Efficacy and tolerance of Elohes in plasma exchanges]
B Guidet1, F Staikowsky, T Vassal
1Service de Réanimation polyvalente, Hôpital Saint-Antoine, Paris.
Annales Francaises D'Anesthesie Et De Reanimation
|January 1, 1992
Summary
This study compared albumin alone versus albumin and hydroxyethylstarch (HES) for plasma exchange (PE). Both regimens demonstrated similar hemodynamic and biochemical tolerance in patients undergoing PE.
Area of Science:
- Critical Care Medicine
- Nephrology
- Cardiovascular Medicine
Background:
- Plasma exchange (PE) requires fluid replacement to maintain hemodynamic stability.
- Albumin and hydroxyethylstarch (HES) are commonly used plasma substitutes.
Purpose of the Study:
- To compare the efficacy and tolerance of two plasma substitution regimens during PE.
- To evaluate the use of albumin alone versus a combination of albumin and low molecular weight HES (Elohes).
Main Methods:
- Prospective, cross-over randomized trial with 12 patients.
- Each patient underwent two PE sessions at 48-hour intervals.
- Regimens included albumin alone (PEA) or albumin plus HES (PEA+E).
Main Results:
- PE duration, plasma volume extracted, and substitute volume infused were comparable between PEA and PEA+E.
- No significant differences were observed in heart rate, blood pressure, or central venous pressure (CVP).
- Clinical and biological tolerance was assessed for both regimens.
Conclusions:
- Both albumin and albumin-HES regimens are well-tolerated during PE.
- The choice of plasma substitute may not significantly impact hemodynamic parameters in PE.
- Further research could explore long-term outcomes and specific patient populations.