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Macroporous poly(epsilon-caprolactone) with antimicrobial activity obtained by iodine polymerization.
Kleber de Arruda Almeida1, Alvaro Antonio Alencar de Queiroz, Olga Zazuco Higa
1Departamento de Física e Química/Instituto de Ciências, Universidade Federal de Itajubá (UNIFEI), Av. BPS. 1303, 37500-903, Itajubá, Minas Gerais, Brasil.
Journal of Biomedical Materials Research. Part A
|February 6, 2004
Summary
A novel poly(caprolactone)-iodine (PCL-I(2)) macroporous iodophor was synthesized to combat infections from biomedical devices. This PCL-I(2) material demonstrated effective antimicrobial activity and was non-cytotoxic.
Area of Science:
- Biomaterials Science
- Infectious Disease Research
- Polymer Chemistry
Background:
- Infections associated with implanted biomedical devices pose a significant mortality risk.
- There is a critical need for effective antimicrobial strategies to prevent device-related infections.
Purpose of the Study:
- To synthesize and characterize a novel macroporous iodine-based sanitizer, poly(caprolactone)-iodine (PCL-I(2)).
- To evaluate the in vitro cytotoxicity and antimicrobial efficacy of the developed PCL-I(2) iodophor.
Main Methods:
- Synthesis of macroporous poly(caprolactone)-iodine (PCL-I(2)).
- Characterization using nuclear magnetic resonance spectroscopy, gel permeation chromatography, nitrogen adsorption-desorption, and scanning electron microscopy.
- In vitro assessment of cytotoxicity against Chinese hamster ovary (CHO) cells and antimicrobial activity against Escherichia coli and Staphylococcus aureus.
Main Results:
- The synthesized PCL-I(2) formed macroporous structures with a narrow size distribution.
- The PCL-I(2) iodophor exhibited no significant cytotoxicity towards CHO cells.
- Antimicrobial testing revealed effective activity against both E. coli and S. aureus, with greater efficacy against E. coli.
Conclusions:
- The developed macroporous PCL-I(2) iodophor is a promising candidate for preventing infections associated with biomedical devices.
- The material's non-cytotoxic nature and potent antimicrobial properties support its potential clinical application.