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Female sterilization with quinacrine using hysterosalpingography (HSG) as an endpoint after a single-insertion
A Giugni Chalbaud1, G Plaza Mora
1Concepción Palacios Maternity Hospital, Caracas, Venezuela. aldoyu@hotmail.com
Objective:
To evaluate the intrauterine insertion of quinacrine as an alternative nonsurgical female sterilization method by confirming bilateral occlusion of the fallopian tubes using HSG in a group of women who desire permanent sterilization.
Methods:
After doing hysterosalpingography to confirm patency of both fallopian tubes, 324 mg of quinacrine were introduced with a modified IUD inserter in 30 patients who came to Concepción Palacios Maternity Hospital seeking permanent sterilization, between June 2000 and September 2001. Follow-up with HSG was done 3 months later to verify occlusion of the fallopian tubes.
Results:
26 of 30 patients (86%) had bilateral tubal occlusion as determined by HSG. There were minor side effects such as: pain (66.7%), yellow discharge (100%) and menstrual abnormalities (13.3%). One woman became pregnant after HSG showed bilateral occlusion. HSG may interfere with the action of the quinacrine.
Conclusion:
QS is a simple and safe alternative to surgical sterilization with few side effects.
