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Updated: Aug 29, 2026

Three-Dimensional Cell Culture Models to Investigate the Epithelial Barrier in Eosinophilic Esophagitis
Published on: May 10, 2024
The idiopathic hypereosinophilic syndrome
1Harvard Medical School, Departments of Medicine and Pediatrics, Brigham and Women's Hospital, Boston, Massachusetts, USA.
Abstract:
Idiopathic hypereosinophilic syndrome (IHES) is characterized by sustained (> 6 months) peripheral eosinophilia (> 1500 cells/mm3), organ damage, and exclusion of other causes. IHES is clinically and pathogenetically heterogenous, and several potential disease mechanisms have been described. The prognosis for patients with IHES has improved with targeted therapies and aggressive management of complications. We report a case of IHES and review the clinical features, evaluation, and options for treatment.
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