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[Malaria during pregnancy: consequences and interventional perspectives].

M Cot¹, P Deloron

¹IRD (Institut de Recherche pour le Développement), UR 010, faculté de pharmacie, laboratoire de parasitologie, 4 avenue de l'observatoire, 75270, Paris. michel.cot@ird.fr

Medecine Tropicale : Revue Du Corps De Sante Colonial

|February 7, 2004

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Malaria prevention during pregnancy, especially in endemic areas, significantly reduces maternal anemia and low birthweight (LBW). Chemoprophylaxis is recommended as a routine public health measure for pregnant women.

Area of Science:

Obstetrics and Gynecology
Infectious Diseases
Public Health

Context:

Malaria in pregnancy poses significant risks, varying by transmission intensity.
Complications include maternal anemia and low birthweight (LBW), particularly in first pregnancies.
HIV co-infection exacerbates placental malaria frequency and severity.

Purpose:

To evaluate the impact of malaria chemoprophylaxis in pregnant women in stable endemic areas.
To assess the effectiveness of prophylaxis on birthweight and maternal anemia.
To inform public health recommendations for malaria prevention in pregnancy.

Summary:

Controlled trials since 1964 show malaria chemoprophylaxis increases mean birthweight and reduces anemia in pregnant women, especially primigravidae.

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Prevention is less effective in HIV-co-infected women, suggesting a need for higher doses.

Sulfadoxine-pyrimethamine is recommended for routine antenatal care due to parasite resistance to chloroquine.

Impact:

Actively promoting malaria prophylaxis as a routine public health measure is crucial for pregnant women in endemic regions.
Integrating prophylaxis into antenatal care enhances overall prevention efficacy.
New therapeutic and vaccinal approaches are being developed based on placental malaria molecular receptor research.