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[Purulent meningitis in children: special considerations for developing countries].

P Reinert1

  • 1Service de pédiatrie, Centre Hospitalier Intercommunal de Créteil, 40 avenue de Verdun, 94010 Créteil. philippe.reinert@chicreteil.fr

Medecine Tropicale : Revue Du Corps De Sante Colonial
|February 7, 2004
PubMed
Summary

Bacterial meningitis is a significant threat in tropical regions due to epidemics and lack of vaccination. New vaccines combining Haemophilus influenzae type b, meningococcal types a and W135, and pneumococcal serotypes are crucial for improved child immunization.

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Area of Science:

  • Tropical infectious diseases
  • Vaccinology
  • Epidemiology

Context:

  • Bacterial meningitis, particularly meningococcal and pneumococcal, poses a significant public health challenge in tropical zones, exacerbated by recurring epidemics and limited vaccination coverage.
  • The emergence of antibiotic-resistant strains of Streptococcus pneumoniae and the unexplained rise of Neisseria meningitidis W135 strains in Burkina Faso complicate treatment and control efforts.

Purpose:

  • To highlight the epidemiological challenges of bacterial meningitis in tropical regions.
  • To discuss the limitations of current vaccines and the need for broader coverage.
  • To advocate for the development and implementation of comprehensive conjugate vaccines.

Summary:

  • Bacterial meningitis is prevalent in tropical areas, driven by meningococcal epidemics and inadequate Haemophilus influenzae type b (Hib) vaccination.

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  • The emergence of meningococcal W135 and antibiotic-resistant pneumococcal strains increases disease burden and treatment costs.
  • A future conjugate vaccine combining Hib, meningococcal A and W135, and additional pneumococcal serotypes is proposed to enhance protection.

    • Impact:

    • Improved immunization strategies are essential to reduce the incidence and mortality of bacterial meningitis in tropical regions.
    • The development of a multi-valent conjugate vaccine could significantly increase vaccine effectiveness against key meningitis pathogens.
    • Achieving 85% coverage for pneumococcal meningitis may require a vaccine including four additional serotypes beyond the current 7-valent formulation.