Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[How should an immunodeficiency be explored?].

F Le Deist1

  • 1Laboratoire d'immunologie pédiatrique, hôpital Necker-Enfants Malades AP-HP, 149, rue de Sèvres, 75743 Paris, France. ledeist@necker.fr

Archives De Pediatrie : Organe Officiel De La Societe Francaise De Pediatrie
|February 7, 2004
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Reconstitution of maturating and regulatory lymphocyte subsets after cord blood and BMT in children.

Bone marrow transplantation·2012
Same author

[Epidemiology of autoimmune haemolytic anemia in children: French data].

Archives de pediatrie : organe officiel de la Societe francaise de pediatrie·2006
Same author

[Evans' syndrome: a retrospective study from the ship (French Society of Pediatric Hematology and Immunology) (36 cases)].

Archives de pediatrie : organe officiel de la Societe francaise de pediatrie·2005
Same author

Transient familial haemophagocytic lymphohistiocytosis reactivation post-CD34 haematopoietic stem cell transplantation.

British journal of haematology·2005
Same author

Coombs' negative haemolytic anaemia as a first manifestation of autoimmune lymphoproliferative disease.

British journal of haematology·2005
Same author

Impact of HLA matching on outcome of hematopoietic stem cell transplantation in children with inherited diseases: a single-center comparative analysis of genoidentical, haploidentical or unrelated donors.

Bone marrow transplantation·2004
Same journal

Family experiences of paediatric palliative care during hospital-at-home: a systematic review.

Archives de pediatrie : organe officiel de la Societe francaise de pediatrie·2026
Same journal

Knowledge of maternity caregivers on vaccination BCG recommendations and circuits.

Archives de pediatrie : organe officiel de la Societe francaise de pediatrie·2026
Same journal

"CRANIOQUALITY study: Quality of life in children with non-syndromic craniosynostosis after surgery".

Archives de pediatrie : organe officiel de la Societe francaise de pediatrie·2026
Same journal

Chronological evolution of brain imaging of hemiconvulsion-hemiplegia-epilepsy from 5 cases in Mayotte island.

Archives de pediatrie : organe officiel de la Societe francaise de pediatrie·2026
Same journal

Point-of-care capillary blood ketone testing to predict the need for intravenous or nasogastric tube rehydration in children with acute gastroenteritis.

Archives de pediatrie : organe officiel de la Societe francaise de pediatrie·2026
Same journal

Transition practices of patients with inflammatory bowel disease from pediatric to adult healthcare systems. Results from a national survey.

Archives de pediatrie : organe officiel de la Societe francaise de pediatrie·2026
See all related articles

Simple blood tests and clinical evaluation help diagnose immunodeficiency. Early identification of lymphopenia and neutropenia guides further specific testing for immune disorders.

Area of Science:

  • Clinical Immunology
  • Pediatric Hematology

Context:

  • Immunodeficiency diagnosis requires careful interpretation of early laboratory findings.
  • Physiological variations in young children can complicate initial assessments.

Purpose:

  • To outline essential initial investigations for suspected immunodeficiency.
  • To highlight the diagnostic value of blood cell counts and immunoglobulin levels.

Summary:

  • Lymphopenia, indicating cellular immunity deficits, is often missed in young children due to normal hyperlymphocytosis.
  • Neutropenia below 500/mm3 is a significant clinical sign of potential immune compromise.
  • Serum immunoglobulin (IgG, IgA, IgM) levels are interpretable after 4-5 months of age.
  • Combined with medical history and clinical exam, these simple tests direct further specialized immunodeficiency investigations.

Related Experiment Videos

Impact:

  • Facilitates earlier and more accurate diagnosis of primary immunodeficiencies.
  • Improves patient outcomes by enabling timely targeted therapies.
  • Reduces unnecessary investigations by guiding clinicians toward specific diagnostic pathways.