Related Experiment Video
Updated: Aug 29, 2026

Vessel-Sparing Microsurgical Longitudinal Intussusception Vasoepididymostomy to Treat Epididymal Obstructive Azoospermia
Published on: May 27, 2022
[Non-obstructive azoospermia: 2 new cases of Sertoli cell only syndrome]
Antonio Jalón Monzón1, José Luis Martín Benito, Jorge García Rodríguez
1Servicio de Urología, Servicio de Genética, Hospital Universitario Central de Asturias, Oviedo, Asturias, España.
Objectives:
We report 2 cases of Sertoli cell only syndrome and perform a bibliographic review.
Methods:
Clinical and pathologic study of 2 male patients 33 and 37-year-old respectively who presented with infertility.
Results:
Testicular biopsy, the most important diagnostic test in the study of infertile men, showed bilateral Sertoli cell only syndrome.
Conclusions:
The Sertoli cell only syndrome is an entity in which seminiferous tubules show a total absence of germ cells with Sertoli cells alone. Etiology is unknown in most cases. Testicular biopsy is performed in these azoospermic men to rule out tubular obstruction or abnormalities of the spermatogenesis. Assisted reproduction techniques are a therapeutic option, making genetic counselling necessary due to the risk of transmission of the genetic defects that cause male infertility.
Related Concept Videos
Spermatogenesis
Spermatogenesis
The process of spermatogenesis can be divided into mitosis, meiosis, and spermiogenesis. During mitosis, the spermatogonia or stem cells divide to produce two identical daughter cells, type A and B spermatogonia. Type-A...
Infertility in Males
Meiosis II
The timing and cell division patterns of meiosis differ between males and females. In male meiosis, the centrosomes are part of the formation of the meiotic spindle. However, in oocytes, including that of humans, Drosophila,...
Meiosis II
Nondisjunction

