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Related Experiment Videos

Continuous venovenous hemofiltration without anticoagulation.

Shigehiko Uchino1, Nigel Fealy, Ian Baldwin

  • 1Department of Intensive Care, Austin Hospital, Melbourne, Australia.

ASAIO Journal (American Society for Artificial Internal Organs : 1992)
|February 7, 2004
PubMed
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Continuous venovenous hemofiltration (CVVH) without anticoagulation is safe and effective for critically ill patients at risk of bleeding. This approach achieved acceptable circuit life, comparable to standard anticoagulation methods.

Area of Science:

  • Nephrology
  • Critical Care Medicine
  • Intensive Care Unit Management

Background:

  • Anticoagulation is standard for continuous venovenous hemofiltration (CVVH) to ensure circuit patency.
  • Patients at risk of bleeding often require modified or omitted anticoagulation strategies.
  • Assessing the efficacy and safety of CVVH without anticoagulation is crucial for this patient population.

Purpose of the Study:

  • To evaluate the efficacy and safety of continuous venovenous hemofiltration (CVVH) without anticoagulation in critically ill patients.
  • To compare circuit life and bleeding complications between CVVH with no anticoagulation, low-dose heparin, and regional anticoagulation.

Main Methods:

  • Prospective observational study involving 48 critically ill patients undergoing CVVH.

Related Experiment Videos

  • Data collected included anticoagulation status (none, low-dose heparin, regional), circuit life, and bleeding complications.
  • Laboratory parameters such as platelet count, PT-INR, and aPTT were monitored.

    • Main Results:

    • Out of 300 circuits, 143 (47.6%) received no anticoagulation.
    • No bleeding complications were reported in any group.
    • Mean circuit life was similar across groups: heparin (20.9 hrs), no anticoagulation (19.3 hrs), and protamine (21.2 hrs).

    Conclusions:

    • Continuous venovenous hemofiltration (CVVH) without anticoagulation is a viable option for critically ill patients with bleeding risks.
    • This strategy demonstrates acceptable circuit longevity, comparable to standard anticoagulation protocols.
    • Further research may explore optimizing CVVH protocols for specific patient populations.