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Updated: Dec 30, 2025

Antimicrobial Peptides Produced by Selective Pressure Incorporation of Non-canonical Amino Acids
Published on: May 4, 2018
Acremonidins, new polyketide-derived antibiotics produced by Acremonium sp., LL-Cyan 416
Haiyin He1, Ramunas Bigelis, Eric H Solum
1Natural Products Research, Chemical and Screening Sciences, Wyeth Research, 401 N. Middletown Road, Pearl River, NY 10965, USA. heh@wyeth.com
Abstract:
Acremonidins A to approximately E (1 to approximately 5) were produced by fermentation of Acremonium sp., LL-Cyan 416, in heterogeneous phases. The structures of these compounds, containing a bridging keto group, were determined by spectroscopic analysis. Acremonidins A and B showed moderate activity against Gram-positive bacteria, including the methicillin-resistant staphylococci and vancomycin-resistant enterococci. Selective acylations of acremonidin B afforded ester derivatives 6 to approximately 9 that exhibited improved antibacterial activity.
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