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Updated: Aug 29, 2026
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Apolipoprotein E polymorphism and neuropsychological outcome following subarachnoid haemorrhage
Paul Graham Morris1, J T Lindsay Wilson, Laurence T Dunn
1Department of Psychiatry, Royal Edinburgh Hospital, University of Edinburgh, Edinburgh, UK. p.g.morris@ed.ac.uk
Objectives:
To investigate the association between APOE genotype and cognitive and emotional outcome following spontaneous subarachnoid haemorrhage (SAH).
Materials And Methods:
Neuropsychological assessments were conducted with 70 SAH survivors derived from a consecutive series of neurosurgical admissions. Outcomes, including cognitive tests, health questionnaires and Glasgow Outcome Scale at a mean of 16 months after SAH, were compared with presence or absence of the epsilon4 allele.
Results:
There was no evidence that SAH survivors possessing the epsilon4 allele had poorer outcome. The only suggestion of an association between the epsilon4 allele and outcome was in a subgroup of patients with a Fisher grade 4 haemorrhage, although this trend did not reach statistical significance.
Conclusions:
Overall, possession of the APOE epsilon4 allele is not significantly associated with neuropsychological outcome following SAH. However, there may be an effect amongst those with a Fisher grade 4 haemorrhage.
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