Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Regional differences in oesophageal motor function.

J L Wise1, J A Murray, J L Conklin

  • 1Department of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN 55905, USA.

Neurogastroenterology and Motility
|February 7, 2004
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Small intestinal microbial fiber metabolism dysfunction in celiac disease.

Research square·2025
Same author

Site-Specific and Temporal Effects of Apraglutide, a Novel Long-Acting Glucagon-Like Peptide-2 Receptor Agonist, on Intestinal Growth in Mice.

The Journal of pharmacology and experimental therapeutics·2020
Same author

The Bearing of the Experimental Induction of Cancer on Our Conceptions of Its Nature and Causation.

Glasgow medical journal·2018
Same author

Natural history and clinical detection of undiagnosed coeliac disease in a North American community.

Alimentary pharmacology & therapeutics·2018
Same author

Editorial: a novel approach to monitor mucosal healing in coeliac disease-as simple as shifting goalposts? Authors' reply.

Alimentary pharmacology & therapeutics·2017
Same author

Chemotherapeutic Researches on Cancer. A Review.

Bristol medico-chirurgical journal (1883)·2017
Same journal

Recognizing Suspected Colonic Hypercompliance in Refractory Constipation When Barostat Testing Is Unavailable-Authors' Reply.

Neurogastroenterology and motility·2026
Same journal

Accuracy of Novice Raters for Esophageal Motility Classifications Using Functional Lumen Imaging Probe Panometry.

Neurogastroenterology and motility·2026
Same journal

Letter to the Editor: "Magnesium-Rich Mineral Water Improves Stool Consistency and Bowel Habits in Healthy Subjects: A Randomized Controlled Trial".

Neurogastroenterology and motility·2026
Same journal

The Drought of Evidence for Water Intake to Manage Constipation Symptoms May Be Ending.

Neurogastroenterology and motility·2026
Same journal

L-Carnitine Improves Visceral Hypersensitivity and Colonic Hyperpermeability in a Rat Model of Irritable Bowel Syndrome.

Neurogastroenterology and motility·2026
Same journal

Letter to the Editor: "Magnesium-Rich Mineral Water Improves Stool Consistency and Bowel Habits in Healthy Subjects: A Randomized Controlled Trial".

Neurogastroenterology and motility·2026
See all related articles

Esophageal function differs between the proximal and distal regions, influenced by bolus viscosity and body position. Multichannel intraluminal impedance revealed these key differences in esophageal motor function.

Area of Science:

  • Gastroenterology
  • Physiology

Background:

  • Esophageal bolus transit and motor function are crucial for digestion.
  • Understanding regional variations and influencing factors is essential for diagnosing motility disorders.

Purpose of the Study:

  • To investigate regional differences in esophageal bolus transit and motor function.
  • To determine the impact of bolus viscosity and body position on esophageal function.

Main Methods:

  • Healthy volunteers underwent testing using multichannel intraluminal impedance.
  • Measurements included bolus head advance time, bolus presence time, and bolus transit time.
  • Concurrent manometric responses were compared for water and viscous materials in upright and supine positions.

Main Results:

Related Experiment Videos

  • Transit times were longer in the distal esophagus for both water and viscous swallows, in upright and supine positions.
  • Water swallows resulted in shorter overall transit times compared to viscous swallows.
  • Peristaltic pressure wave amplitudes were reduced with viscous swallows and varied regionally.

Conclusions:

  • Significant functional differences exist between the proximal and distal esophagus.
  • Bolus viscosity is a key determinant of esophageal motor function.
  • Body position also influences esophageal transit and motor patterns.