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Related Experiment Videos

Expansive arterial remodeling: location, location, location.

Gerard Pasterkamp1, Zorina S Galis, Dominique P V de Kleijn

  • 1Heart Lung Institute, Laboratory of Experimental Cardiology, Utrecht University Hospital, Utrecht, The Netherlands. g.pasterkamp@hli.azu.nl

Arteriosclerosis, Thrombosis, and Vascular Biology
|February 7, 2004
PubMed
Summary

Arterial expansive remodeling, a compensatory response to atherosclerosis, involves inflammation and proteolysis, leading to thrombotic plaques. This "wolf in sheep

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Area of Science:

  • Vascular biology
  • Cardiovascular pathology
  • Arterial remodeling

Background:

  • Arteries dynamically adapt geometry to atherosclerosis.
  • Expansive remodeling, a compensatory mechanism, increases vessel diameter to counteract luminal narrowing.
  • Despite its compensatory nature, expansive remodeling is linked to adverse plaque characteristics.

Purpose of the Study:

  • To discuss the "wolf in sheep's clothes" phenomenon of expansive arterial remodeling.
  • To highlight the association of expansive remodeling with inflammation, proteolysis, and thrombotic plaques.
  • To explore the role of inflammation and protease activity in different arterial remodeling modes.

Main Methods:

  • Review of literature on arterial remodeling in atherosclerosis.

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  • Analysis of the pathological features of expansively remodeled lesions.
  • Discussion of the molecular mechanisms underlying arterial remodeling.

    • Main Results:

    • Expansive remodeling, while retarding luminal narrowing, is characterized by inflammatory cell infiltration.
    • Proteolysis and a pro-thrombotic plaque phenotype are consistently observed in expansively remodeled arteries.
    • Inflammation and protease activity are implicated in the development of various arterial remodeling patterns.

    Conclusions:

    • Expansive arterial remodeling is a complex response with detrimental consequences.
    • Inflammatory processes and protease activity are key drivers in the pathogenesis of atherosclerotic plaque development and remodeling.
    • Understanding these mechanisms is crucial for developing targeted therapies for atherosclerosis.