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Updated: Aug 29, 2026

Generation and 3-Dimensional Quantitation of Arterial Lesions in Mice Using Optical Projection Tomography
Published on: May 26, 2015
Expansive arterial remodeling: location, location, location
Gerard Pasterkamp1, Zorina S Galis, Dominique P V de Kleijn
1Heart Lung Institute, Laboratory of Experimental Cardiology, Utrecht University Hospital, Utrecht, The Netherlands. g.pasterkamp@hli.azu.nl
Abstract:
The artery is a dynamic organ capable of changing its geometry in response to atherosclerotic plaque formation. Expansion of the vessel diameter retards luminal narrowing and is considered a compensatory response. However, the expansive remodeling response is a "wolf in sheep's clothes," because expansion is associated with the presence of inflammatory cells, proteolysis, and a thrombotic plaque phenotype. The prevalence and clinical presentation of expansively remodeled lesions may differ among vascular beds. However, it is evident that all types of atherosclerotic arterial expansive lesions share the presence of inflammatory cells and subsequent protease activities. The potential role of inflammation and protease activity in the development of the different remodeling modes is discussed.
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