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Updated: Aug 29, 2026

Uracil-DNA Glycosylase Assay by Matrix-assisted Laser Desorption/Ionization Time-of-flight Mass Spectrometry Analysis
Published on: April 22, 2022
MALDI-TOF mass spectrometry: a versatile tool for high-performance DNA analysis
Christian Jurinke1, Paul Oeth, Dirk van den Boom
1Sequenom, Inc., Johns Hopkins Court, San Diego, CA 92121, USA. cjurinke@sequenom.com
Abstract:
Matrix-assisted laser desorption/ionization (MALDI) time-of-flight (TOF) mass spectrometry (MS) has developed during the past decade into a versatile tool for biopolymer analysis. The aim of this review is to summarize this development and outline the applications, which have been enabled for routine use in the field of nucleic acid analysis. These include the analysis of mutations, the resequencing of amplicons with a known reference sequence, and the quantitative analysis of gene expression and allelic frequencies in complex DNA mixtures.
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