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Updated: Aug 29, 2026

Generation of Hypoparathyroid Rats via Carbon-Nanoparticle-Assisted Parathyroidectomy
Published on: July 14, 2023
The coronary effects of parathyroid hormone
Réka Fazekas1, Pál Soós, Violetta Kékesi
1Department of Cardiovascular Surgery, Semmelweis University Budapest, Budapest, Hungary.
Objective:
The aim of the present study was to characterize the role of the ATP-sensitive potassium channels (K(+)(ATP)) in the coronary dilator action of parathyroid hormone (PTH).
Methods:
Dose-response curves of intracoronary administrated PTH (0.15-1.33 nmol) were obtained in control phases and during continuous intracoronary administration of the K(+)(ATP) channel-selective antagonist glibenclamide (0.1-1.0 micromol/min) in dogs (n = 13).
Results:
Increments of integrated coronary conductance (excess coronary conductance) at PTH doses of 0.15 and 1.33 nmol were 1.17 versus 0.03 ml/mm Hg (p < 0.05) and 4.03 versus 0.94 ml/mm Hg (p < 0.05) in the control versus during maximal blockade, respectively.
Conclusion:
The results indicate that the activation of K(+)(ATP) channels significantly contributes to the PTH-induced coronary vasodilation.
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