Jove
Visualize
Contact Us

Related Experiment Videos

The functional interactions between the p53 and MAPK signaling pathways.

Gen Sheng Wu1

  • 1Program in Molecular Biology and Human Genetics, Karmanos Cancer Institute, Department of Pathology, Wayne State University School of Medicine, Room E216, The Prentis Building, 110 East Warren Avenue, Detroit, Michigan 48201, USA. wug@karmanos.org

Cancer Biology & Therapy
|February 7, 2004
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Regulation of PD-L1 Protein Expression by the E3 Ubiquitin Ligase GP78.

Current issues in molecular biology·2025
Same author

Correction: Potential role for Cathepsin D in p53-dependent tumor suppression and chemosensitivity.

Oncogene·2025
Same author

Correction: Identification of TRAIL-inducing compounds highlights small molecule ONC201/TIC10 as a unique anti-cancer agent that activates the TRAIL pathway.

Molecular cancer·2024
Same author

Autophagy and cancer therapy.

Cancer letters·2024
Same author

The role of the immune response and inflammatory pathways in TNF-related apoptosis-inducing ligand (TRAIL) resistance in triple-negative breast cancer cells.

American journal of cancer research·2023
Same author

The Role of TRAIL in Apoptosis and Immunosurveillance in Cancer.

Cancers·2023
Same journal

Integrative single-cell and spatial transcriptomic approaches to decipher the tumor microenvironment and therapeutic resistance in pancreatic cancer.

Cancer biology & therapy·2026
Same journal

Effective treatment of human breast tumors by chimeric CCL2 and CCL8 diphtheria toxin cytotoxic peptides.

Cancer biology & therapy·2026
Same journal

<i>NSUN2</i> mediates <i>SALL2</i> m5C methylation to inhibit ferroptosis and promote breast cancer progression.

Cancer biology & therapy·2026
Same journal

Targeting the PI3K/AKT pathway in prostate cancer: the role of PTEN deficiency and biomarker-guided therapy.

Cancer biology & therapy·2026
Same journal

ABHD17C regulates the efficacy of lenvatinib in suppressing hepatocellular carcinoma.

Cancer biology & therapy·2026
Same journal

Advances in SEC61G research: from ER translocon subunit to emerging pan-cancer oncogenic roles.

Cancer biology & therapy·2026
See all related articles
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

The p53 protein interacts with mitogen-activated protein kinase (MAPK) pathways, influencing cell growth and apoptosis. Understanding this crosstalk is crucial for cancer research, as both pathways are frequently altered in tumors.

Area of Science:

  • Molecular Biology
  • Cell Signaling
  • Oncology

Background:

  • The p53 tumor suppressor protein regulates cell growth and survival through diverse signaling pathways.
  • p53 activation, often by stress stimuli, involves phosphorylation by protein kinases and acts as a transcription factor.
  • Dysregulation of p53 and MAPK pathways is common in human cancers.

Purpose of the Study:

  • To explore the functional interactions between the p53 and mitogen-activated protein kinase (MAPK) signaling pathways.
  • To elucidate how these interactions contribute to cellular responses like cell cycle arrest and apoptosis.
  • To investigate the role of p53 in regulating MAPK signaling and vice versa.

Main Methods:

  • Review of existing literature on p53 and MAPK signaling.

Related Experiment Videos

  • Analysis of molecular mechanisms underlying p53-MAPK crosstalk.
  • Examination of transcriptional regulation of MAPK pathway components by p53.

    • Main Results:

    • p53 functionally interacts with MAPK pathways, including JNK, p38 MAPK, and ERK.
    • MAP kinases phosphorylate and activate p53 in response to stress, mediating cellular outcomes.
    • p53 can act as an upstream regulator of MAPK signaling through phosphatase gene activation.

    Conclusions:

    • The interplay between p53 and MAPK signaling is a critical determinant of cell fate.
    • Understanding this crosstalk offers potential insights into deregulated proliferation and survival in cancer.
    • Targeting the p53-MAPK axis may represent a novel therapeutic strategy for cancer treatment.