Related Experiment Video
Updated: Aug 29, 2026

09:54
Lentiviral Vector-mediated Gene Therapy of Hepatocytes Ex Vivo for Autologous Transplantation in Swine
Published on: November 4, 2018
Lactose-appended schizophyllan is a potential candidate as a hepatocyte-targeted antisense carrier
Teruaki Hasegawa1, Mariko Umeda, Takahiro Matsumoto
1Department of Chemistry and Biotechnology, Graduate School of Engineering, Kyushu University, Hakozaki 6-10-1, Higashi-ku, Fukuoka 812-8581, Japan.
Abstract:
A schizophyllan (beta-1,3-glucan) derivative carrying lactose-appendages prepared by reductive amination can form stable macromolecular complexes with polynucleotides, shows excellent affinity with a lactose-binding lectin, and effectively mediates gene transfection into hepatocytes.
