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[Renal function in hypertensive patients with obstructive sleep apnea].

N J Büchner1, B F Henning, K F Hägele

  • 1Medizinische Klinik I am Marienhospital Herne, Klinikum der Ruhr-Universität Bochum. nikolaus.buechner@ruhr-uni-bochum.de

Deutsche Medizinische Wochenschrift (1946)
|February 7, 2004
PubMed
Summary

Obstructive sleep apnea (OSA) is independently associated with impaired renal function, indicated by higher serum creatinine levels. This suggests a link between sleep apnea and kidney health, warranting further investigation into underlying mechanisms.

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Area of Science:

  • Nephrology
  • Sleep Medicine
  • Cardiology

Background:

  • Hypertension is common in patients with obstructive sleep apnea (OSA).
  • Factors like hypoxemia and increased sympathetic nerve activity in OSA may worsen kidney function.
  • The study aimed to compare renal function between OSA patients with and without hypertension.

Purpose of the Study:

  • To investigate the relationship between obstructive sleep apnea (OSA) and renal function.
  • To determine if hypertension modifies the association between OSA and kidney function.
  • To correlate polysomnographic findings with renal and metabolic parameters.

Main Methods:

  • 81 patients were screened for sleep apnea.
  • Renal function (serum creatinine, creatinine clearance, microalbuminuria) and metabolic parameters were assessed.

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  • Polysomnographic results were correlated with clinical and laboratory data.

    • Main Results:

    • OSA was diagnosed in 57 of 81 patients, with a mean apnea-hypopnea index (AHI) of 26.7.
    • Serum creatinine was significantly higher in OSA patients compared to non-OSA patients (1.11 vs. 0.91 mg/dl).
    • Serum creatinine correlated positively with AHI; creatinine clearance showed a trend towards association with OSA presence.

    Conclusions:

    • An independent association exists between obstructive sleep apnea (OSA) and impaired renal function.
    • Hypertension was not directly correlated with serum creatinine or creatinine clearance in this OSA cohort.
    • Further research is needed to clarify the pathophysiological links between OSA and kidney dysfunction.