Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

Prognostic factors for low-grade gliomas.

Roger Stupp¹, Robert C Janzer, Monika E Hegi

¹Multidisciplinary Oncology Center, University Hospital (CHUV), 46, Rue du Bugnon, CH-1011 Lausanne, Switzerland.

Seminars in Oncology

|February 7, 2004

Summary

Identifying prognostic factors for low-grade gliomas is crucial for patient management. A new prognostic score helps determine whether to initiate treatment or wait for tumor progression.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Temozolomide Versus Radiotherapy as First-Line Therapy for Low-Grade Glioma: Mature Results of a Randomized Phase III Trial (EORTC 22033-26033/NCIC-CTG/TROG/MRC-CTU).

Journal of clinical oncology : official journal of the American Society of Clinical Oncology·2026

Same author

Development of skull-implanted ultrasound for blood-brain barrier opening and drug delivery in neuro-oncology.

Neuro-oncology advances·2026

Same author

The perinecrotic niche of glioblastoma drives tumor-associated macrophage polarization and immunosuppression via podoplanin-mediated CLEC5A activation.

The Journal of clinical investigation·2026

Same author

Phase 1 evaluation of patients with newly diagnosed glioblastoma treated with radiation, nivolumab, and IDO1 enzyme inhibitor BMS-986205.

Clinical cancer research : an official journal of the American Association for Cancer Research·2026

Same author

Fully Humanized Bispecific T Cell Engager Shows Potent Activity in Central Nervous System and Peripheral Tumors.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2026

Same author

20 years of the Stupp protocol: confronting stagnation in glioblastoma therapy.

The Lancet. Oncology·2026

Area of Science:

Neuro-oncology
Brain Tumor Research

Background:

Low-grade gliomas are diverse primary brain tumors with variable progression rates.
Tumor, patient, and molecular factors influence survival, but optimal treatment strategies remain unclear.

Purpose of the Study:

To review prognostic factors for low-grade gliomas.
To discuss the utility of a new prognostic score for guiding treatment decisions.

Main Methods:

Retrospective analysis of tumor, patient, and treatment-related prognostic factors.
Review of recursive partitioning and multivariant analyses.
Discussion of the European Organisation for Research and Treatment of Cancer (EORTC) prognostic score.

Main Results:

Tumor histology, grade, location, contrast enhancement, and molecular markers are significant prognostic factors.

Related Experiment Videos

Patient age, performance status, and seizure history also impact prognosis.

A favorable prognostic score suggests withholding treatment until progression, while a high-risk score may warrant immediate treatment.

Conclusions:

Accurate prognostic factor identification is essential for effective low-grade glioma management.
The EORTC prognostic score aids in risk stratification and treatment planning.
Further research is needed to establish optimal therapeutic sequences beyond surgery.