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Related Experiment Videos

Thresholds for decrease in intracellular pH and increase in blood lactate during progressive exercise: 31P-MRS study.

K Iwanaga1, M Sakurai, T Minami

  • 1Saga Research Institute, Otsuka Pharmaceutical Co., Ltd.

The Annals of Physiological Anthropology = Seiri Jinruigaku Kenkyukai Kaishi
|November 1, 1992
PubMed
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This study compared muscle energy metabolism during arm exercise. Lactic acidosis occurred before significant intracellular pH changes, suggesting it

Area of Science:

  • Exercise Physiology
  • Biochemistry
  • Muscle Metabolism

Background:

  • Understanding the relationship between intramuscular and intravascular metabolic events during exercise is crucial for interpreting physiological responses.
  • Previous research has explored energy metabolism, but direct comparisons of intramuscular pH and plasma lactate kinetics during progressive arm exercise are limited.

Purpose of the Study:

  • To compare intramuscular and intravascular events related to energy metabolism during progressive arm exercise.
  • To investigate the relationship between changes in intracellular pH and plasma lactate concentration.
  • To identify potential physiological indices of muscle fatigue.

Main Methods:

  • Utilized 31P-Magnetic Resonance (MR) spectroscopy to measure intracellular pH (pHT) and phosphocreatine/inorganic phosphate (Pi/PCr) ratios in wrist flexor muscles.

Related Experiment Videos

  • Monitored plasma lactate concentration (La) in venous blood samples collected at one-minute intervals.
  • Determined exercise thresholds for pH decline (pHT), Pi/PCr increase (PT), and lactate increase (LT) using piecewise linear regression analysis.

    • Main Results:

    • The threshold for plasma lactate increase (LT) occurred at a significantly lower percentage of maximal work rate (24.8%) compared to the thresholds for intracellular pH decline (pHT, 43.0%) and Pi/PCr increase (PT, 42.5%).
    • Intracellular pH remained relatively stable until approximately 43% of maximal work rate.
    • Plasma lactate concentration began to rise earlier, indicating the onset of lactic acidosis before significant intracellular metabolic disturbances were detected.

    Conclusions:

    • Lactic acidosis may precede detectable changes in intracellular pH during progressive arm exercise.
    • The threshold for intracellular pH decline (pHT) may reflect the capacity of remaining intracellular biochemical homeostasis.
    • pHT could serve as a physiological index for muscle fatigue during exercise.